683 Xerosis cutis and its association with chronic inflammatory illnesses

Disruption in skin barrier is associated with increased systemic inflammatory markers. It unknown whether this epidermal disturbance, clinically manifested as xerosis cutis (XC), linked to illnesses. Using Epic Slicer Dicer, we collected cross-sectional, retrospective data on patients ≥ 50 (N=6384) over a 5-year period (March 2015-March 2020). Patients ICD-10 diagnosis code of XC were identified and association chronic illnesses explored comparison control group. Stata was used calculate odds ratios (OR), 95% confidence intervals (CI), p-values. Caucasian male female both 1.3 times more likely develop type II diabetes (OR 1.3,CI 1.1-1.6,P=0.007;OR 1.0-1.6,P=0.026, respectively) 1.4 essential hypertension 1.4,CI 1.2-1.7,P<0.0001;OR 1.2-1.6,P=0.0001). African American 2.8 2.2 2.8,CI 1.4-5.5,P=0.001;OR 2.2,CI 1.3-4.0,P=0.003), but only males 9.4 9.4,CI 4.6-20.9,P<0.0001). atherosclerosis 1.7-2.8,P<0.0001) hyperlipidemia 1.1-1.5,P=0.0004), while 2.9 2.9,CI 1.3-6.2,P=0.007) no significant hyperlipidemia. 1.6 1.7 osteoporosis 1.6,CI 1.1-2.3,P=0.007;OR 1.7,CI 1.4-2.0,P<0.0001), 3.5 depression 3.5,CI 1.5-7.9,P=0.003). Xerosis specific The cytokines seen may contribute these diseases. Additional research needed further elucidate link explore the role restoration management disorders.